产品编号 | 产品名称 | CAS No. |
DC8299 |
VER155008
VER-155008 is a novel, small molecule inhibitor of Hsc70/Hsp70 with GI50 of 5.3-14.4 uM in human breast and colon cancer cell lines. |
1134156-31-2 |
DC8382 |
PF-03084014 (Nirogacestat)
PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Phase 2. |
1290543-63-3 |
DC8429 |
Verdinexor (KPT-335)
Verdinexor (KPT-335) is an orally bioavailable, selective XPO1/CRM1 inhibitor. |
1392136-43-4 |
DC8435 |
LY2119620
LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. |
886047-22-9 |
DC8440 |
Erythromycin Cyclocarbonate
Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome. |
55224-05-0 |
DC8443 |
ESI-09
ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA. |
263707-16-0 |
DC8444 |
Sabutoclax
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. |
1228108-65-3 |
DC8454 |
Nutlin-3a
Nutlin-3a is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. |
675576-98-4 |
DC8457 |
BMS-309403
BMS309403 is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E. |
300657-03-8 |
DC8459 |
Palovarotene(R 667)
Palovarotene (R-667, RO-3300074) is a selective retinoic acid receptor gamma(RAR-γ) agonist for the treatment of emphysema. |
410528-02-8 |
DC8471 |
CGS 21680 hydrochloride
CGS 21680 hydrochloride is an A2A adenosine receptor agonist (Ki = 27 nM). |
124431-80-7 |
DC8487 |
Gemcitabine elaidate
Gemcitabine elaidate is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. |
210829-30-4 |
DC8534 |
α-Amyloid Precursor Protein Modulator
α-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. |
497259-23-1 |
DC8537 |
AZ505
AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 uM) with potential anticancer activity, >600 fold than SMYD3(IC50>83.3 uM); DOT1L(IC50>83.3 uM);EZH2(IC50>83.3 uM). |
1035227-43-0 |
DC8539 |
DM1-SMCC
DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make antibody drug conjugate. |
1228105-51-8 |
DC8540 |
DM-1(Mertansine)
A cytotoxic agent used in antibody-drug conjugates |
139504-50-0 |
DC8565 |
AVN944
AVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2. |
297730-17-7 |
DC8586 |
LY2801653
LY2801653 is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). |
1206799-15-6 |
DC8592 |
Sivelestat (sodium salt hydrate)
Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
201677-61-4 |
DC8623 |
AM966
AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors. |
1228690-19-4 |
DC8630 |
Ralimetinib 2MsOH(LY2228820)
LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively). |
862507-23-1 |
DC8638 |
Paclitaxel
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. |
33069-62-4 |