产品编号 | 产品名称 | CAS No. |
DC7711 |
Losmapimod
Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. Phase 3. |
585543-15-3 |
DC7727 |
PH-797804
PH-797804 is a potent and selective p38 inhibitor with IC50 of 26 nM. |
586379-66-0 |
DC7745 |
Filorexant(mk-6096)
MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia. |
1088991-73-4 |
DC7751 |
FLLL32
FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor. |
1226895-15-3 |
DC7755 |
TRCP6 inhibitor(SAR7334)
TRPC6 inhibitor is a potent TRPC6(Transient receptor potential cation channel, subfamily C, member 6) inhibitor. |
1333207-63-8 |
DC7807 |
SB 239063
SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. |
193551-21-2 |
DC7833 |
NS309
NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels. |
18711-16-5 |
DC7836 |
Doramapimod (BIRB-796)
BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ. |
285983-48-4 |
DC7867 |
AMG-837
AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
865231-46-5 |
DC7868 | AS703026(Pimasertib) | 1236699-92-5 |
DC7886 |
TTNPB
TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively. |
71441-28-6 |
DC7906 |
AZ20
AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR. |
1233339-22-4 |
DC7956 |
SP2509
SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B. |
1423715-09-6 |
DC7989 |
PEPA
PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. |
141286-78-4 |
DC8004 |
AZD6482
AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ. |
1173900-33-8 |
DC8053 |
PU-WS13
PU-WS13 is a cell-permeable compound that selectively binds to Grp94 and inhibits its activity (EC50=220 nM). |
1454619-14-7 |
DC8116 |
Tosedostat (CHR2797)
CHR-2797 is an aminopeptidase inhibitor, with IC50 values of 100 nM for LAP3 (LAP), 150 nM for PSAP (PuSA) and 220 nM for CD13 (Aminopeptidase N). |
238750-77-1 |
DC8131 |
TAPI-2 (TNF Protease Inhibitor 2)
TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 µM, respectively. |
187034-31-7 |
DC8133 |
Batimastat(BB-94)
Batimastat was used to study the role of MMP in proteolytic release of EGF in human follicular thyroid carcinoma cell line FTC-133. |
130370-60-4 |
DC8257 |
GNE 477
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR. |
1032754-81-6 |
DC8261 |
(-)-JQ-1
The (-)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains,it is the negative control of +JQ-1. |
1268524-71-5 |
DC8283 |
PD 150606
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). |
179528-45-1 |