产品编号 | 产品名称 | CAS No. |
DC7506 |
Sotrastaurin
Sotrastaurin(AEB-071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM; inactive to PKCζ. |
425637-18-9 |
DC7508 |
SU 5402
SU5402(SU-5402; SU5402) is potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor. (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). |
215543-92-3 |
DC7513 |
TCS 1102
TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). |
916141-36-1 |
DC7516 |
TG100-115
TG100115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2. |
677297-51-7 |
DC7539 |
SIRT2 Inhibitor II, AK-1
SIRT2 Inhibitor II, AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3. |
330461-64-8 |
DC7544 |
CUDC-101
CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1. |
1012054-59-9 |
DC7546 |
LHW090-A7
For the detailed information of LHW090-A7, the solubility of LHW090-A7 in water, the solubility of LHW090-A7 in DMSO, the solubility of LHW090-A7 in PBS buffer, the animal experiment (test) of LHW090-A7, the cell expriment (test) of LHW090-A7, the in viv |
1308256-94-1 |
DC7551 |
RG3039(PF-06687859)
For the detailed information of PF-0668759, the solubility of PF-0668759 in water, the solubility of PF-0668759 in DMSO, the solubility of PF-0668759 in PBS buffer, the animal experiment (test) of PF-0668759, the cell expriment (test) of PF-0668759, the |
1005504-62-0 |
DC7588 |
PNU120596
PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. |
501925-31-1 |
DC7610 |
LDN-57444
LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. |
668467-91-2 |
DC7619 |
Tazarotenic acid (AGN 190299)
Tazarotenic Acid is an agent that acts as the principle active metabolite |
118292-41-4 |
DC7635 |
IB-MECA
IB-MECA is a potent and selective A3 adenosine receptor agonist (Ki values are 1.1, 54 and 56 nM for A3, A1 and A2A receptors respectively). |
152918-18-8 |
DC7691 |
PF 1022A
PF 1022A is a N-methylated cyclooctadepsipeptides (CODPs) with strong anthelmintic properties; acts as an ionophore. |
133413-70-4 |
DC7708 |
UNBS5162
UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers; the mean antiproliferative activity IC50 value is 17.9 uM for 9 cancer cell lines; hydrolysis product of UNBS3157. |
956590-23-1 |
DC7710 |
Lasmiditan (COL-144; LY573144)
Lasmiditan (COL-144; LY573144) is a high-affinity, highly selective 5-HT1F receptor agonist(Ki=2.1 nM), compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. |
439239-90-4 |
DC7711 |
Losmapimod
Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. Phase 3. |
585543-15-3 |
DC7727 |
PH-797804
PH-797804 is a potent and selective p38 inhibitor with IC50 of 26 nM. |
586379-66-0 |
DC7745 |
Filorexant(mk-6096)
MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia. |
1088991-73-4 |
DC7751 |
FLLL32
FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor. |
1226895-15-3 |
DC7755 |
TRCP6 inhibitor(SAR7334)
TRPC6 inhibitor is a potent TRPC6(Transient receptor potential cation channel, subfamily C, member 6) inhibitor. |
1333207-63-8 |
DC7807 |
SB 239063
SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. |
193551-21-2 |
DC7833 |
NS309
NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels. |
18711-16-5 |