产品编号 | 产品名称 | CAS No. |
DC7210 |
LY-303511
LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K. |
154447-38-8 |
DC7216 |
NVP-BSK805 dihydrochloride
NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM; >20-fold selectivity towards JAK1, JAK3 and TYK2. |
1092499-93-8 |
DC7222 |
P005091(P5091)
P005091(P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM. |
882257-11-6 |
DC7230 |
PHA-665752
PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM, >50-fold selectivity for c-Met than RTKs or STKs. |
477575-56-7 |
DC7246 |
SR3677
SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM. |
1072959-67-1 |
DC7249 |
ROCK inhibitor GS269962A
GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. |
850664-21-0 |
DC7294 |
SGX-523
SGX-523 is a selective Met inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. |
1022150-57-7 |
DC7301 |
SSR128129E
SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 μM, while not affecting other related RTKs. |
848318-25-2 |
DC7323 |
Pritelivir(BAY-57-1293)
BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. |
348086-71-5 |
DC7342 |
Foretinib(XL880)
Foretinib (GSK1363089; XL880; EXEL-2880; GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. |
849217-64-7 |
DC7368 |
AZD5363
AZD5363, a novel pyrrolopyrimidine-derived compound, inhibits all AKT isoforms (IC50 <10 nM). |
1143532-39-1 |
DC7397 |
Darapladib
Darapladib is a selective and orally active inhibitor of Lp-PLA2 (IC50= 270 pM) |
356057-34-6 |
DC7404 |
DMXAA
DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively. Phase 3. |
117570-53-3 |
DC7413 |
Fasudil-HA
Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
105628-07-7 |
DC7418 |
GNE-0877
GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. |
1374828-69-9 |
DC7434 |
IWP-L6
IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM. |
1427782-89-5 |
DC7455 |
Lonafarnib
Lonafarnib(Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. |
193275-84-2 |
DC7463 |
Mibefradil-dihydrochloride
Mibefradil 2Hcl(Ro 40-5967) is calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. |
116666-63-8 |
DC7481 |
PHT427
PHT-427 is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively. |
1191951-57-1 |
DC7486 |
PX-478 2HCL
PX-478 is an inhibitor of HIF-1a with an IC50 of 20-30μM enhances radiosensitivity of prostate carcinoma cells. |
685898-44-6 |
DC7494 |
SB-242084 HCl
5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2Breceptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity. |
1049747-87-6 |
DC7500 |
Siramesine-hydrochloride
Siramesine(Lu 28-179) Hcl is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. |
224177-60-0 |