T-5224

产品编号: DC8024 Featured
T-5224
结构式
530141-72-1
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中国地区超过5000个高品质化合物库存
应用领域
T-5224 是选择性的转录因子 c-Fos/activator protein (AP)-1 抑制剂,具有抗炎活性,能特异性抑制 c-Fos/c-Jun 的 DNA 结合活性,而不影响其他转录因子的结合活性。T-5224 抑制 IL-1β 诱导的 Mmp-3、Mmp-13、Adamts-5 转录上调。
Cas No.: 530141-72-1
名称: 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxybenzo[d]isoxazol-6-yl)methoxy)phenyl)propanoic acid
别名: T-5224; T5224; T 5224.
SMILES: C(CCC(O)=O)1=CC(C(=O)C2=CC=C(OC3CCCC3)C=C2O)=CC=C1OCC1=CC2=C(C=C1)C(=O)NO2
分子式: C29H27NO8
分子量: 517.53
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1, attenuates lipopolysaccharide-induced liver injury in mice.T-5224 was converted to its acyl O-glucuronide (G2) by UGT1A1 and UGT1A3 and to its hydroxyl O-glucuronide (G3) by several UGTs, but it was not metabolized by the P450s . For the detailed information of T-5224, the solubility of T-5224 in water, the solubility of T-5224 in DMSO, the solubility of T-5224 in PBS buffer, the animal experiment (test) of T-5224, the cell expriment (test) of T-5224, the in vivo, in vitro and clinical trial test of T-5224, the EC50, IC50,and affinity,of T-5224, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_2076_DC8024_530141-72-1
COA
LOT NO. DOWNLOAD
产品编号 产品名称 应用领域
DC8024 T-5224 T-5224 是选择性的转录因子 c-Fos/activator protein (AP)-1 抑制剂,具有抗炎活性,能特异性抑制 c-Fos/c-Jun 的 DNA 结合活性,而不影响其他转录因子的结合活性。T-5224 抑制 IL-1β 诱导的 Mmp-3、Mmp-13、Adamts-5 转录上调。