R1487

产品编号: DC10053 Featured
R1487
结构式
449811-92-1
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中国地区超过5000个高品质化合物库存
应用领域
6-(2,4-二氟苯氧基)-8-甲基-2-[(四氢-2H-吡喃-4-基)氨基]-吡啶并[2,3-d]嘧啶-7(8h)-酮
Cas No.: 449811-92-1
名称: 6-(2,4-difluorophenoxy)-8-methyl-2-(oxan-4-ylamino)pyrido[2,3-d]pyrimidin-7-one
别名: R-1487,R 1487
SMILES: CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC4CCOCC4
分子式: C19H19CIF2N4O3
分子量: 388.37
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study For rheumatoid arthritis. The original lead, an lck inhibitor that also potently inhibited p38α, was a screening hit from our kinase inhibitor library. This manuscript describes the optimization of the lead to p38-selective examples with good pharmacokinetic properties.For the detailed information of R1487, the solubility of R1487 in water, the solubility of R1487 in DMSO, the solubility of R1487 in PBS buffer, the animal experiment (test) of R1487, the cell expriment (test) of R1487, the in vivo, in vitro and clinical trial test of R1487, the EC50, IC50,and Affinity of R1487, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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