2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study For rheumatoid arthritis. The original lead, an lck inhibitor that also potently inhibited p38α, was a screening hit from our kinase inhibitor library. This manuscript describes the optimization of the lead to p38-selective examples with good pharmacokinetic properties.For the detailed information of R1487, the solubility of R1487 in water, the solubility of R1487 in DMSO, the solubility of R1487 in PBS buffer, the animal experiment (test) of R1487, the cell expriment (test) of R1487, the in vivo, in vitro and clinical trial test of R1487, the EC50, IC50,and Affinity of R1487, Please contact DC Chemicals.
