RITA (NSC652287)

产品编号: DC1064 Featured
RITA (NSC652287)
结构式
213261-59-7
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中国地区超过5000个高品质化合物库存
应用领域
RITA 是一种有效的 p53-HDM-2 相互作用抑制剂,可与 p53dN 结合,Kd 值为 1.5 nM,同时能够诱导 DNA-DNA 交联。
Cas No.: 213261-59-7
名称: 2-Thiophenemethanol, 5,5'-(2,5-furandiyl)bis-
别名: NSC-652287, NSC 652287
SMILES: C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
分子式: C14H12O3S2
分子量: 292.37
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: RITA is an anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo. For the detailed information about the solubility of RITA (NSC 652287) in water, the solubility of RITA (NSC 652287) in DMSO, the solubility of RITA (NSC 652287) in PBS buffer, the animal experiment(test) of RITA (NSC 652287),the in vivo,in vitro and clinical trial test of RITA (NSC 652287),the cell experiment(test) of RITA (NSC 652287),the IC50, EC50 and Affinity of RITA (NSC 652287), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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