TPEN

产品编号: DC2081 Featured
TPEN
结构式
16858-02-9
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中国地区超过5000个高品质化合物库存
应用领域
TPEN 是一种特异性的可渗透细胞的重金属螯合剂。
Cas No.: 16858-02-9
名称:
别名:
SMILES: N(CC1=NC=CC=C1)(CC2=NC=CC=C2)CCN(CC3=NC=CC=C3)CC4=NC=CC=C4
分子式: C26H28N6
分子量: 424.54
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: TPEN is a cell permeable, high-affinity heavy metal (Zn2+>Fe2+>Mn2+) chelator that exhibits low affinity For Mg2+ and Ca2+. The compound is lipid-soluble and has been shown to permeate artificial and natural membranes. Research shows that TPEN induces apoptosis in human and rat thymocytes through DNA fragmentation and Caspace-3 activation. TPEN also induces mitochondrial cytochrome C translocation to the cytosol in human PBL. A recent study has proved this chelator to work in conjunction with the fluorescent probe Fura-2 (sc-202163) in biophysical studies of Ca2+. For the detailed information about the solubility of TPEN in water, the solubility of TPEN in DMSO, the solubility of TPEN in PBS buffer, the animal experiment(test) of TPEN, the in vivo,in vitro and clinical trial test of TPEN, the cell experiment(test) of TPEN, the IC50, EC50 and Affinity of TPEN , please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_1059_DC2081_16858-02-9
COA
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