2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
TPEN is a cell permeable, high-affinity heavy metal (Zn2+>Fe2+>Mn2+) chelator that exhibits low affinity For Mg2+ and Ca2+. The compound is lipid-soluble and has been shown to permeate artificial and natural membranes. Research shows that TPEN induces apoptosis in human and rat thymocytes through DNA fragmentation and Caspace-3 activation. TPEN also induces mitochondrial cytochrome C translocation to the cytosol in human PBL. A recent study has proved this chelator to work in conjunction with the fluorescent probe Fura-2 (sc-202163) in biophysical studies of Ca2+.
For the detailed information about the solubility of TPEN in water, the solubility of TPEN in DMSO, the solubility of TPEN in PBS buffer, the animal experiment（test） of TPEN, the in vivo,in vitro and clinical trial test of TPEN, the cell experiment（test） of TPEN, the IC50, EC50 and Affinity of TPEN , please contact DC Chemicals.
