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EW-7197

产品编号: DC8342 Featured
EW-7197
结构式
1352608-82-2
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中国地区超过5000个高品质化合物库存
应用领域
Vactosertib (EW-7197) 是一种有效的，具有口服活性且具有 ATP 竞争性激活素受体样激酶 5 (ALK5) 抑制剂，IC50 为 12.9 nM。Vactosertib 还以纳摩尔浓度抑制 ALK2 和 ALK4 (IC50 为 17.3 nM)。Vactosertib 具有强大的抗转移活性和抗癌作用。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 1352608-82-2
名称: N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline
别名: EW-7197，EW 7197，EW7197,TEW-7197; NOV-1301
SMILES: N(CC1NC(C2=NC(C)=CC=C2)=C(C2=CN3N=CN=C3C=C2)N=1)C1=CC=CC=C1F
分子式: C22H18FN7
分子量: 399.42
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: EW-7197 is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy. EW-7197 inhibits TGF-β/Smad signaling. EW-7197 abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung.EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotopic grafted mice. For the detailed information of EW-7197, the solubility of EW-7197 in water, the solubility of EW-7197 in DMSO, the solubility of EW-7197 in PBS buffer, the animal experiment (test) of EW-7197, the cell expriment (test) of EW-7197, the in vivo, in vitro and clinical trial test of EW-7197, the EC50, IC50,and affinity,of EW-7197, For the detailed information of EW-7197, the solubility of EW-7197 in water, the solubility of EW-7197 in DMSO, the solubility of EW-7197 in PBS buffer, the animal experiment (test) of EW-7197, the cell expriment (test) of EW-7197, the in vivo, in vitro and clinical trial test of EW-7197, the EC50, IC50,and affinity,of EW-7197, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC8342 EW-7197 Vactosertib (EW-7197) 是一种有效的，具有口服活性且具有 ATP 竞争性激活素受体样激酶 5 (ALK5) 抑制剂，IC50 为 12.9 nM。Vactosertib 还以纳摩尔浓度抑制 ALK2 和 ALK4 (IC50 为 17.3 nM)。Vactosertib 具有强大的抗转移活性和抗癌作用。
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