| Cas No.: | 1168091-68-6 |
| 名称: | 5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide; RG 7421 |
| 别名: | G-868 |
| SMILES: | FC(C=C(I)C=C1)=C1NC2=C(C(NOCCO)=O)C=CC3=CN=CN23 |
| 分子式: | C16H14FIn4O3 |
| 分子量: | 456.21 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
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| In Vitro: | |
| References: | GDC-0623 is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) versus A375 (BRAF(V600E), EC50=7 nM). For the detailed information of GDC-0623, the solubility of GDC-0623 in water, the solubility of GDC-0623 in DMSO, the solubility of GDC-0623 in PBS buffer, the animal experiment (test) of GDC-0623, the cell expriment (test) of GDC-0623, the in vivo, in vitro and clinical trial test of GDC-0623, the EC50, IC50,and affinity,of GDC-0623, Please contact DC Chemicals. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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