产品编号 | 产品名称 | CAS No. |
DC2070 |
pan-Akt inhibitor GS690693
GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
937174-76-0 |
DC3133 |
NVP-BGT226 (BGT226)
NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM. |
1245537-68-1 |
DC7047 |
AICAR (Acadesine)
Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3. |
2627-69-2 |
DC7210 |
LY-303511
LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K. |
154447-38-8 |
DC7481 |
PHT427
PHT-427 is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively. |
1191951-57-1 |
DC7516 |
TG100-115
TG100115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2. |
677297-51-7 |
DC8004 |
AZD6482
AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ. |
1173900-33-8 |
DC8257 |
GNE 477
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR. |
1032754-81-6 |
DC9335 |
AT7867
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family. |
857531-00-1 |
DC9879 |
AZD8835
AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM). |
1620576-64-8 |