产品编号 | 产品名称 | CAS No. |
DC7886 |
TTNPB
TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively. |
71441-28-6 |
DC7906 |
AZ20
AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR. |
1233339-22-4 |
DC8382 |
PF-03084014 (Nirogacestat)
PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Phase 2. |
1290543-63-3 |
DC8443 |
ESI-09
ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA. |
263707-16-0 |
DC8459 |
Palovarotene(R 667)
Palovarotene (R-667, RO-3300074) is a selective retinoic acid receptor gamma(RAR-γ) agonist for the treatment of emphysema. |
410528-02-8 |
DC8487 |
Gemcitabine elaidate
Gemcitabine elaidate is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. |
210829-30-4 |
DC8534 |
α-Amyloid Precursor Protein Modulator
α-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. |
497259-23-1 |
DC8565 |
AVN944
AVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2. |
297730-17-7 |
DC8586 |
LY2801653
LY2801653 is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). |
1206799-15-6 |
DC8638 |
Paclitaxel
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. |
33069-62-4 |
DC8649 |
1-Methyl-7-nitroisatoic anhydride
1-methyl-7-nitroisatoic anhydride is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity. |
73043-80-8 |
DC8693 |
Epiandrosterone
Epiandrosterone is a steroid hormone with weak androgenic activity. Epiandrosterone is naturally produced by the enzyme 5α-reductase from the adrenal hormone DHEA. |
481-29-8 |
DC8710 |
Tranylcypromine HCl
Tranylcypromine HCl is an inhibitor of monoamine oxidase (MAO) and prostacyclin synthase, potently suppresses the enzymatic activity of Lysine-Specific Demethylase 1 (LSD1) (IC50 <2 μM for BHC110/LSD1). |
1986-47-6 |
DC8735 |
AHU-377 hemicalcium salt
AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM. |
1369773-39-6 |
DC8738 |
Sal003
Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility. |
1164470-53-4 |
DC8792 |
Pirfenidone(AMR69)
Pirfenidone(AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Phase 3. |
53179-13-8 |
DC8855 |
Fumagillin
Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis. |
23110-15-8 |
DC8953 |
6-TG/Thioguanine
6-Thioguanine(6-TG) belongs to the thiopurine family of drugs that also include mercaptopurine and azathioprine, which are examples of antimetabolites; it is a purine analogue of the nucleobase guanine. |
154-42-7 |
DC8972 |
Carmustine
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent. |
154-93-8 |
DC8985 |
Riluzole
Riluzole is a glutamate antagonist used as an anticonvulsant and to prolong the survival of patients with amyotrophic lateral sclerosis. |
1744-22-5 |
DC8988 |
Imiquimod
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
99011-02-6 |
DC9003 |
Triamterene
Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. |
396-01-0 |