产品编号 | 产品名称 | CAS No. |
DC3105 |
BMS-599626 (AC480)
BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively. |
714971-09-2 |
DC3133 |
NVP-BGT226 (BGT226)
NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM. |
1245537-68-1 |
DC3170 |
Cediranib
Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM. |
288383-20-0 |
DC4174 |
NVP-AEW541
NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM. |
475489-16-8 |
DC4175 |
BMS-911543
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, approximately 350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. |
1271022-90-2 |
DC4182 |
Temozolomide
Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer. |
85622-93-1 |
DC4196 |
Bleomycin Sulfate
Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells. |
9041-93-4 |
DC4232 |
Vismodegib (GDC-0449)
Vismodegib (formerly GDC-0449) is a hedgehog antagonist, is also an orally bioavailable small molecule with potential antineoplastic activity. |
879085-55-9 |
DC5032 |
AZD1480
AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1/2. |
935666-88-9 |
DC5049 |
RAF265 (CHIR-265)
RAF265 (CHIR-265) is a highly selective B-Raf and VEGFR2 inhibitor with IC50 of 3-60 nM and EC50 of 30 nM, including B-Raf, C-Raf and mutant B-Raf. |
927880-90-8 |
DC5086 |
Ixazomib(MLN2238)
MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. |
1072833-77-2 |
DC5159 |
CP-868596 (Crenolanib)
Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB |
670220-88-9 |
DC5882 |
Fosbretabulin disodium
Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. |
168555-66-6 |
DC6909 |
Entinostat (MS-275)
Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10. Phase 1/2. |
209783-80-2 |
DC7056 |
AMG-208
AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM. |
1002304-34-8 |
DC7069 |
Daunorubicin HCL
Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. |
23541-50-6 |
DC7081 |
PF-04217903
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant). |
956905-27-4 |
DC7114 |
Dinaciclib (SCH727965)
Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. |
779353-01-4 |
DC7177 |
JNJ 38877605
JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. |
943540-75-8 |
DC7186 |
LGK-974
LGK-974 is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM. |
1243244-14-5 |
DC7191 |
LY-2940680(Taladegib)
LY2940680 binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. |
1258861-20-9 |
DC7294 |
SGX-523
SGX-523 is a selective Met inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. |
1022150-57-7 |