| References: |
XL147 analogue is a Class 1 PI3K kinase family inhibitor, and is an orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents including genotoxic agents and receptor tyrosine kinase inhibitors. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of XL147 (SAR245408) in water, the solubility of XL147 (SAR245408) in DMSO, the solubility of XL147 (SAR245408) in PBS buffer, the animal experiment（test） of XL147 (SAR245408),the in vivo,in vitro and clinical trial test of XL147 (SAR245408),the cell experiment（test） of XL147 (SAR245408),the IC50, EC50 and Affinity of XL147 (SAR245408), please contact DC Chemicals. |
