TG101209
产品编号: DC7317
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应用领域
TG101209 是一种选择性的，有效的 JAK2 抑制剂，IC50 值为 6 nM；同时能抑制 Flt3，和 RET 的活性，IC50 值分别为 25 nM 和 17 nM。
| Cas No.: |
936091-14-4 |
| 名称: |
N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide |
| 别名: |
TG 101209; TG-101209 |
| SMILES: |
C(S(NC(C)(C)C)(=O)=O)1=CC=CC(NC2C(C)=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=2)=C1 |
| 分子式: |
C26H35N7O2S |
| 分子量: |
509.67 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
TG101209 is an orally bioavailable, small molecule, ATP-competitive inhibitor towards several tyrosine kinases. TG101209 inhibits growth of Ba/F3 cells expressing JAK2V617F or MPLW515L mutations with an IC50 of B200 nM. In a human JAK2V617F-expressing acu |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
| 2018-0101 |
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