MK-4101
产品编号: DC9707
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应用领域
MK-4101 是一种 SMO 拮抗剂 (对 293 细胞的 IC50 为 1.1 µM)，也是一种有效的 hedgehog 途径抑制剂 (对小鼠细胞的 IC50 为 1.5 µM；对 KYSE180 食管癌细胞的 IC50 为 1 µM)。MK-4101 具有强大的抗肿瘤活性，能抑制肿瘤细胞增殖并诱导细胞凋亡。
| Cas No.: |
935273-79-3 |
| 名称: |
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| 别名: |
MK4101,MK 4101,MK-4101 |
| SMILES: |
C1(=CC=CC=C1C1N(C)C(C23CCC(C4=NOC(C5CC(F)(F)C5)=N4)(CC2)CC3)=NN=1)C(F)(F)F |
| 分子式: |
C24H24F5N5O |
| 分子量: |
493.47 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma.MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice.K-4101 induce deregulation of cell cycle and block of DNA replication in tumors. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1. MK-4101 also induce deregulation of cell cycle and block of DNA replication in tumors. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2736_DC9707_935273-79-3 |
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COA
| LOT NO. |
DOWNLOAD |
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