RAF265 (CHIR-265)
产品编号: DC5049
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应用领域
RAF265 (CHIR-265) is a highly selective B-Raf and VEGFR2 inhibitor with IC50 of 3-60 nM and EC50 of 30 nM, including B-Raf, C-Raf and mutant B-Raf.
| Cas No.: |
927880-90-8 |
| 名称: |
1-methyl-5-(2-(4-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine |
| 别名: |
CHIR265,RAF-265,CHIR 265, |
| SMILES: |
FC(F)(C1=CN=C(N1)C2=NC=CC(OC3=CC=C4N(C(NC5=CC=C(C(F)(F)F)C=C5)=NC4=C3)C)=C2)F |
| 分子式: |
C24H16F6N6O |
| 分子量: |
518.41 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM.
IC50 value: 3-60 nM (B-Raf); 30 nM(EC50 for VEGFR2)
Target: B-Raf; VEGFR2; B-R |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_3386_DC5049_927880-90-8 |
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COA
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DOWNLOAD |
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