RO 5028442

产品编号: DC10583 Featured
RO 5028442
结构式
920022-47-5
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中国地区超过5000个高品质化合物库存
应用领域
RG7713 (RO5028442) 是一种高效且有选择性的脑-渗透加压素 1a (V1a) 受体拮抗剂,其 Ki 值为 1 nM (hV1a) 和 39 nM (mV1a)。
Cas No.: 920022-47-5
名称:
别名: RO-5028442; RO 5028442; RO5028442
SMILES: O=C(C1=CN(CCN(C)C)C2=C1C=CC(Cl)=C2)N3CCC4(CC3)OCC5=C4C=CC=C5
分子式: C25H28ClN3O2
分子量: 437.96
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: In Vitro: Compounds 29, 31, and RO5028442 (compound 8) have excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. All compounds show high solubility. RO5028442 is found to be highly selective against a panel of 89 targets. Finally, RO5028442 is identified as a suitable compound for clinical studies.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC10583 RO 5028442 RG7713 (RO5028442) 是一种高效且有选择性的脑-渗透加压素 1a (V1a) 受体拮抗剂,其 Ki 值为 1 nM (hV1a) 和 39 nM (mV1a)。