| Cas No.: | 908115-27-5 |
| 名称: | (1r,4r)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate |
| 别名: | SNX5422,PF 04929113,SNX 5422,PF-04929113, |
| SMILES: | CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C |
| 分子式: | C25H30F3N5O4 |
| 分子量: | 521.53 |
| 纯度: | |
| 保存条件: | 4°C for 1 year, -20°C for more than 2 years |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM). PF-04929113 is a small-molecule Hsp90 inhibitor based on the 6,7-dihydro-indazol-4-one scaffold. PF-04929113 exhibits potent effects on Her-2 stability and causes expected up-regulation of Hsp70. PF-04929113 shows potent antiproliferative activity against a broad range of cancer cell types, e.g. MCF-7 (IC50=16 nM), SW620 (IC50 of 19 nM), K562 (IC50 of 23 nM), SK-MEL-5 (IC50 of 25 nM), and A375 (IC50 of 51 nM). |
| Kinase Assay: | |
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| Animal Administration: | |
| References: |
MSDS
| TITLE | DOWNLOAD |
| MSDS_3568_DC9948_908115-27-5 |
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COA
| LOT NO. | DOWNLOAD |
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