AKI-7169(Aurora Kinase Inhibitor III)

产品编号: DC26118 Featured
AKI-7169(Aurora Kinase Inhibitor III)
结构式
879127-16-9
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中国地区超过5000个高品质化合物库存
应用领域
Aurora Kinase Inhibitor 3 是一种有效的,选择性 Aurora A 激酶抑制剂,IC50 为 42 nM,同时微弱抑制 EGFR,IC50>10 μM。Aurora Kinase Inhibitor 3 的环丙烷羧酸部分指向 ATP 结合口袋的溶剂暴露区域,并且与其他公开的 AIK 结构相比,活性位点中存在几种诱导的结构变化。
Cas No.: 879127-16-9
名称: N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-cyclopropanecarboxamide
别名: AKI-7169,AKI 7169,AKI7169
SMILES: O=C(C1CC1)NC2=CC=CC(NC3=NC=CC(NC4=CC=CC(C(F)(F)F)=C4)=N3)=C2
分子式: C21H18F3N5O
分子量: 413.4
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM). It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively).
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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