ML221

产品编号: DC10793 Featured
ML221
结构式
877636-42-5
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中国地区超过5000个高品质化合物库存
应用领域
ML221 是一种 apelin (APJ) 拮抗剂,抑制 apelin-13 介导的 APJ 的活化,在 cAMP 试验和 β-arrestin 实验中,IC50 值分别为 0.70 μM 和 1.75 μM,EC80 值均为 10 nM。
Cas No.: 877636-42-5
名称: [4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate
别名: ML221; ML 221; ML-221
SMILES: O=C(OC1=COC(CSC2=NC=CC=N2)=CC1=O)C3=CC=C([N+]([O-])=O)C=C3
分子式: C17H11N3O6S
分子量: 385.35
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Displays >37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations >50 μM.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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