ZK756326 2HCl

产品编号: DC10638 Featured
ZK756326 2HCl
结构式
874911-96-3
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中国地区超过5000个高品质化合物库存
应用领域
2-[2-[4-[(3-苯氧基苯基)甲基]-1-哌嗪基]乙氧基]乙醇
Cas No.: 874911-96-3
名称:
别名:
SMILES: OCCOCCN1CCN(CC1)CC2=CC=CC(OC3=CC=CC=C3)=C2.Cl.Cl
分子式: C21H28N2O3.2HCl
分子量: 429.38
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: In vitro: ZK 756326 stimulated extracellular acidification in cells expressing human CCR8. The ability of ZK 756326 to induce a response was receptor-specific and mediated through Gαi, because it could be blocked by treatment with pertussis toxin. Like CCL1, ZK 756326 inhibited human immunodeficiency virus (HIV) fusion of cells expressing CD4 and CCR8. But unlike mCCL1, ZK 756326 bound to and activated a form of mCCR8 that was mutated to eliminate O-linked sulfation at tyrosines 14 and 15. Therefore, ZK 756326 is most probably not binding in the same manner as CCL1 but can activate the switch mechanism involved in transducing signaling events.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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