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Aftin-4

产品编号: DC10844 Featured
Aftin-4
结构式
866893-90-5
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中国地区超过5000个高品质化合物库存
应用领域
Aftin-4 是 β-淀粉样蛋白42 (Aβ42) 的诱导剂。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 866893-90-5
名称: (2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol Amyloid-β Forty-Two Inducer 4 N6-Methyl-(R)-roscovitine
别名: Aftin-4,Aftin 4,Aftin4
SMILES: CC[C@H](CO)NC1=NC(N(C)CC2=CC=CC=C2)=C3C(N(C(C)C)C=N3)=N1
分子式: C20H28N6O
分子量: 368.48
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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