TD-4208
产品编号: DC8813
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应用领域
Revefenacin (TD-4208;GSK1160724) 是有效的 mAChR 拮抗剂，在M3受体上具有高亲和力，Ki 值为0.18 nM。
| Cas No.: |
864750-70-9 |
| 名称: |
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| 别名: |
TD 4208,TD4208 |
| SMILES: |
C1C=C(NC(OC2CCN(CCN(C(C3C=CC(CN4CCC(C(=O)N)CC4)=CC=3)=O)C)CC2)=O)C(C2C=CC=CC=2)=CC=1 |
| 分子式: |
C35H43N5O4 |
| 分子量: |
597.75 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity . TD-4208 is a potent and selective inhaled muscarinic antagonist with functional lung selectivity and long duration of action in preclinical models of bronchoconstriction. It is currently in development for maintenance treatment of airflow obstruction in patients with COPD. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
