| Cas No.: | 863774-58-7 |
| 名称: | 4-(3-hydroxyphenyl)-7,7-dimethyl-2-sulfanylidene-3,4,6,8-tetrahydro-1H-quinazolin-5-one |
| 别名: | |
| SMILES: | CC1(CC2=C(C(NC(=S)N2)C3=CC(=CC=C3)O)C(=O)C1)C |
| 分子式: | C16H18N2O2S |
| 分子量: | 302.4 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
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| In Vitro: | |
| References: | Eg5 Inhibitor III, Dimethylenastron is a cell-permeable quinazoline-thione compound that acts as a strong, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5. Eg5 Inhibitor III, Dimethylenastron shows little effect on the ATPase activity of kinesin-1, -4, -7 and -10. The compound also inhibits bipolar spindle formation in both HeLa cells and in Xenopus egg extracts and induces cell cycle arrest (~1 μM). Eg5 Inhibitor III, Dimethylenastron is shown to induce mitotic arrest, apoptosis and upregulate Hsp70 in human multiple myeloma cells. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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