OC000459(Timapiprant)

产品编号: DC1026 Featured
OC000459(Timapiprant)
结构式
851723-84-7
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中国地区超过5000个高品质化合物库存
应用领域
Timapiprant (OC000459) 是一种高效选择性的口服型 D 前列腺素受体 2 (DP2,也称为 CRTH2) 拮抗剂。 Timapiprant (OC000459) 有效地置换来自人重组 DP2 (K i=13 nM),大鼠重组DP2 ( K i=3 nM) 和人天然 DP2 ( K i=4 nM) 的 [3H] PGD2。 Timapiprant (OC000459) 抑制肥大细胞激活 Th2 淋巴细胞和嗜酸性粒细胞。
Cas No.: 851723-84-7
名称: 5-​fluoro-​2-​methyl-​3-​(2-​quinolinylmethyl)-​1H-​indole-​1-​acetic acid
别名: OC-000459
SMILES: CC1=C(C2=C(N1CC(=O)O)C=CC(=C2)F)CC3=NC4=CC=CC=C4C=C3
分子式: C21H17FN2O2
分子量: 348.4
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: OC000459 is a once-daily oral CRTH2 antagonist in Phase IIb clinical trials that has demonstrated efficacy in asthma, allergic rhinitis and allergic conjunctivitis along with an excellent safety profile. In private groups it was deciced that OC000459 would be the best available safe antagonist that also could be used For topical use. For the detailed information about the solubility of OC000459 in water, the solubility of OC000459 in DMSO, the solubility of OC000459 in PBS buffer, the animal experiment(test) of OC000459,the in vivo,in vitro and clinical trial test of OC000459,the cell experiment(test) of OC000459,the IC50, EC50 and Affinity of OC000459, please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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COA
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