ROCK inhibitor GS269962A

产品编号: DC7249
ROCK inhibitor GS269962A
结构式
850664-21-0
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中国地区超过5000个高品质化合物库存
应用领域
GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases.
Cas No.: 850664-21-0
名称: N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide
别名:
SMILES: CCN1C2=CC(OC3=CC=CC(NC(C4=CC=C(OCCN5CCOCC5)C=C4)=O)=C3)=NC=C2N=C1C6=NON=C6N
分子式: C29H30N8O5
分子量: 570.6
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM For recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity For ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricte
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_3420_DC7249_850664-21-0
COA
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产品编号 产品名称 应用领域
DC7413 Fasudil-HA Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
DC7249 ROCK inhibitor GS269962A GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases.
DC7246 SR3677 SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM.