Foretinib(XL880)
产品编号: DC7342
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
Foretinib (GSK1363089; XL880; EXEL-2880; GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR.
| Cas No.: |
849217-64-7 |
| 名称: |
N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
| 别名: |
XL-880;EXEL-2880,XL 880 |
| SMILES: |
O=C(NC1=CC=C(C(F)=C1)OC2=C3C=C(C(OCCCN4CCOCC4)=CC3=NC=C2)OC)C5(CC5)C(NC6=CC=C(C=C6)F)=O |
| 分子式: |
C34H34F2N4O6 |
| 分子量: |
632.65 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
XL880 inhibits HGF receptor family tyrosine kinases with IC50 values of 0.4 nM For Met and 3 nM For Ron. XL880 also inhibits KDR, Flt-1, and Flt-4 with IC50 values of 0.9 nM, 6.8 nM and 2.8 nM, respectively. XL880 inhibits colony growth of B16F10, A549 |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_3424_DC7342_849217-64-7 |
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COA
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DOWNLOAD |
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