NVP-BEP800
产品编号: DC4118
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应用领域
VER-82576 (NVP-BEP800) 是一种有效的，可口服的，选择性的 Hsp90 抑制剂，对 Hsp90β 的 IC50 值为 58 nM；VER-82576 同时可较弱地抑制 Grp94 和 Trap-1 的活性，IC50 值分别为 4.1 和 5.5 μM。
| Cas No.: |
847559-80-2 |
| 名称: |
2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide |
| 别名: |
VER-82576,NVP BEP800 |
| SMILES: |
C(N)1=NC(C2=CC(OCCN3CCCC3)=C(Cl)C=C2Cl)=C2C=C(C(NCC)=O)SC2=N1 |
| 分子式: |
C21H23Cl2N5O2S |
| 分子量: |
480.41 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Hsp90. NVP-BEP800 showed activity against a panel of human tumor cell lines and primary human xenografts in vitro at nanomolar con |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
