AS1842856
产品编号: DC10086
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应用领域
AS1842856 是一种特异性的 Foxo1 抑制剂，IC50 为 30 nM，AS1842856 有效抑制自噬 (autophagy)。AS1842856 通过抑制 SIRT1 的表达来抑制 FoxO1 活性。AS1842856 仅通过与 FoxO1 结合而降低 FoxO1 的活性，而不影响其转录和蛋白质表达。
| Cas No.: |
836620-48-5 |
| 名称: |
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| 别名: |
AS 1842856，AS-1842856 |
| SMILES: |
O=C(C1=CN(CC)C2=C(C(N)=C(F)C(NC3CCCCC3)=C2)C1=O)O |
| 分子式: |
C18H22FN3O3 |
| 分子量: |
347.38 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
AS1842856 is a potent and cell-permeable Foxo1 inhibitor with an IC50 of 30 nM.
InVitro: AS1842856 potently inhibits human Foxo1 transactivation and reduces glucose production through the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line.
InVivo: Oral administration of AS1842856 to diabetic db/db mice leads to a drastic decrease in fasting plasma glucose level via the inhibition of hepatic gluconeogenic genes, whereas administration to normal mice has no effect on the fasting plasma glucose level. Treatment with AS1842856 also suppresses an increase in plasma glucose level caused by pyruvate injection in both normal and db/db mice. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_72_DC10086_836620-48-5 |
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COA
| LOT NO. |
DOWNLOAD |
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