GLX351322
产品编号: DC11009
Featured
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
GLX351322 是一种 NADPH 氧化酶 4 (Nox4) 抑制剂，在 NOX4 过表达的细胞中，抑制过氧化氢的产生，IC50 值为 5 μM。
| Cas No.: |
835598-94-2 |
| 名称: |
Ethyl 2-[[2-[4-(furan-2-carbonyl)piperazin-1-yl]acetyl]amino]-5,6-dihydro-4H-cyclopenta-[b]thiophene-3-carboxylate |
| 别名: |
GLX 351322;GLX-351322 |
| SMILES: |
O=C(OCC)C1=C(SC2=C1CCC2)NC(CN3CCN(CC3)C(C4=CC=CO4)=O)=O |
| 分子式: |
C21H25N3O5S |
| 分子量: |
431.507 |
| 纯度: |
|
| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
|
| In Vivo: |
|
| In Vitro: |
|
| References: |
GLX351322 (GLX-351322) is a novel potent inhibitor of NADPH oxidase 4 (Nox4), inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM; dispplays an order of magnitude less activity against NOX2; counteracts non-fasting hyperglycemia and impairs glucose tolerance in HFD-treated male C57BL/6 mice, prevents high-glucose-induced human islet cell reactive oxygen species (ROS) production and death. |
| Kinase Assay: |
|
| Cell Assay: |
|
| Animal Administration: |
|
| References: |
|
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
询盘
