E-64c

产品编号: DC10126 Featured
E-64c
结构式
76684-89-4
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中国地区超过5000个高品质化合物库存
应用领域
E 64c 是半胱氨酸蛋白酶 (cysteine proteases) 天然环氧化物抑制剂的衍生物,也是钙离子激活中性蛋白酶 (CANP) 的抑制剂和组织蛋白酶C (cathepsin C) 的弱不可逆抑制剂。
Cas No.: 76684-89-4
名称: (2S,3S)-3[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-oxiranecarboxylic acid
别名: NSC 694279 Loxistatin Acid, EP 475,E64C,E 64C
SMILES: CC(C)CCNC([C@H](CC(C)C)NC([C@@H]1[C@@H](C(O)=O)O1)=O)=O
分子式: C15H26N2O5
分子量: 314.4
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: E-64c is a synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor isolated from Aspergillus japonicus.E-64c inhibits the cysteine proteases cathepsin B and cathepsin L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.The ethyl ester of E-64c, E-64d, is cell permeable and hydrolyzed in cell culture to E-64c. E-64d arrests the growth of A431 cells in metaphase at concentrations between 20-200 µg/ml.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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