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Lovastatin (MK-803)

产品编号: DC2105
Lovastatin (MK-803)
结构式
75330-75-5
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中国地区超过5000个高品质化合物库存
应用领域
Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent).
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 75330-75-5
名称:
别名: MK803, Lovastatin (MK 803)
SMILES: O=C([C@@H](C)CC)O[C@@H]1[C@@]([C@H]2CC[C@@H](OC3=O)C[C@H](C3)O)([H])C(C=C[C@@H]2C)=C[C@H](C)C1
分子式: C24H36O5
分子量: 404.54
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. Lovastatin inhibits HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), blocking the enzyme-catalyzed trans Formation of 3-hydroxy-3-methylglutaryl CoA into mevalonate. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts cholesterol synthesis, leading to a reduction of circulating low-density lipoproteins. Lovastatin demonstrates arrest of the cell cycle at the G1 phase in bladder carcinoma T24 cells expressing activated p21ras oncoprotein - the posttranslational isoprenylation of the p21ras with mevalonate is crucial For translocation and membrane adhesion of the protein, and blockade of this modification by Lovastatin-induced depletion of cellular mevalonate leads to suspension of cell progress. The signaling activity of epidermal growth factor (EGF) and insulin-like growth factor (IGF-I) are similarly affected by impairment of mevalonate-dependent protein prenylation. Induction of apoptosis by Lovastatin in malignant mesothelioma cells is also ascribed to the inhibition of mevalonate synthesis and posttranslational protein modifications. Lovastatin is a substrate of CYP and Mdr-1. For the detailed information about the solubility of Lovastatin (MK-803) in water, the solubility of Lovastatin (MK-803) in DMSO, the solubility of Lovastatin (MK-803) in PBS buffer, the animal experiment（test） of Lovastatin (MK-803),the in vivo,in vitro and clinical trial test of Lovastatin (MK-803),the cell experiment（test） of Lovastatin (MK-803),the IC50, EC50 and Affinity of Lovastatin (MK-803), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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