| Cas No.: | 72926-24-0 |
| 名称: | N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide |
| 别名: | K858,K-858 |
| SMILES: | C(NC1=NN(C(C)=O)C(C)(C2=CC=CC=C2)S1)(=O)C |
| 分子式: | C13H15N3O2S |
| 分子量: | 277.34 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | K 858 is an ATP-uncompetitive mitotic kinesin Eg5 inhibitor, which does not effect microtubule dynamics. Studies on HCT116 cells indicate that K 858 causes mitotic arrest, cell growth inhibition, and activates caspase-3. It is also believed that K858 inhibits the growth of cancer cells. Studies suggest that K 858 is not neurotoxic in motor coordination. Furthermore, K 858 can be a beneficial tool because unlike similar compounds that inhibit Eg5, K 858 does not form breaks in double stranded DNA. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
| TITLE | DOWNLOAD |
| MSDS_2601_DC9272_72926-24-0 |
|
COA
| LOT NO. | DOWNLOAD |
|
|
