PF-431396
产品编号: DC7941
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应用领域
PF-431396 是粘着斑激酶（FAK）和富含脯氨酸的酪氨酸激酶 2（PYK2）的双重抑制剂（IC50值分别为2和11 nM），PF-431396对BRD4的Kd值为445 nM。
| Cas No.: |
717906-29-1 |
| 名称: |
N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide |
| 别名: |
PF 431396，PF431396 |
| SMILES: |
CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C |
| 分子式: |
C22H21F3N6O3S |
| 分子量: |
506.5 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
PF-431396 is a potent and highly selective pyrimidine-based inhibitor of both Pyk2 and FAK, Consistent with the idea that the tyrosine phosphorylation of Pyk2 and FAK involves an initial autophosphorylation or transphosphorylation step, treating A20 cells |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
