| References: |
Nutlin-3a is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It potently inhibits Mdm2-p53 binding with an IC50 value of 0.09 µM, induces the expression of p53-regulated genes, and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. (−)-Nutlin-3 inhibits the proliferation of exponentially growing human skin and murine fibroblasts with IC50 values of 2.2 and 1.3 µM, respectively, and induces substantial tumor shrinkage in mice expressing LnCaP, 22Rv1 or MHM cancer cell lines when treated orally with a 200 mg/kg dose twice daily for two weeks. For the detailed information of Nutlin-3a, the solubility of Nutlin-3a in water, the solubility of Nutlin-3a in DMSO, the solubility of Nutlin-3a in PBS buffer, the animal experiment (test) of Nutlin-3a, the cell expriment (test) of Nutlin-3a, the in vivo, in vitro and clinical trial test of Nutlin-3a, the EC50, IC50,and affinity,of Nutlin-3a, For the detailed information of Nutlin-3a, the solubility of Nutlin-3a in water, the solubility of Nutlin-3a in DMSO, the solubility of Nutlin-3a in PBS buffer, the animal experiment (test) of Nutlin-3a, the cell expriment (test) of Nutlin-3a, the in vivo, in vitro and clinical trial test of Nutlin-3a, the EC50, IC50,and affinity,of Nutlin-3a, Please contact DC Chemicals. |
