CP-868596 (Crenolanib)
产品编号: DC5159
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB
| Cas No.: |
670220-88-9 |
| 名称: |
1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine. |
| 别名: |
CP-868,596; CP-868596; ARO 002;CP868596 |
| SMILES: |
NC1CCN(C2=CC=CC3=C2N=C(N4C5=CC=C(C=C5N=C4)OCC6(COC6)C)C=C3)CC1 |
| 分子式: |
C26H29N5O2 |
| 分子量: |
443.54 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Crenolanib is an orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_3389_DC5159_670220-88-9 |
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COA
| LOT NO. |
DOWNLOAD |
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