AG-1024 (Tyrphostin)
产品编号: DC7052
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应用领域
AG1024 (Tyrphostin AG 1024) 是一种可逆的，竞争性和选择性的胰岛素样生长因子-1 受体 (IGF-1R) 抑制剂，IC50 为 7 μM。AG1024 抑制胰岛素受体 (IR) 的磷酸化 (IC50=57 μM)。AG1024 诱导细胞凋亡 (apoptosis) 并具有抗癌活性。
| Cas No.: |
65678-07-1 |
| 名称: |
2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile |
| 别名: |
AG1024; Tyrphostin AG 1024 |
| SMILES: |
CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O |
| 分子式: |
C14H13BrN2O |
| 分子量: |
305.17 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
AG-1024 blocks the IGF-1 receptor and IR autophosphorylation with IC50 of 7 μM and 57 μM, respectively. AG-1024 also inhibits the receptor tyrosine kinase activity towards exogenous substrates (TKA) with IC50 values of 18 μM and 80 μM, respectively. AG-1 |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
