Apremilast
产品编号: DC7063
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应用领域
Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 (PDE4) 抑制剂，IC50 为 74 nM。Apremilast 抑制脂多糖 (LPS) 释放 TNF-α，IC50 为 104 nM。
| Cas No.: |
608141-41-9 |
| 名称: |
Acetamide,N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- |
| 别名: |
CC 10004; CC10004; CC-10004 |
| SMILES: |
C(=O)1C2=C(C(NC(C)=O)=CC=C2)C(=O)N1[C@H](C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O |
| 分子式: |
C22H24N2O7S |
| 分子量: |
460.5 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Apremilast is more potent For inhibition of PDE4 compared with cAMP or cGMP hydrolysing enzymes from other PDE families. Apremilast displays a broad pattern of anti-inflammatory activity in a variety of cell types, inhibits TNF-α, IL-12 and IL-23 product |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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