SB-742457(RVT-101)

产品编号: DC8354 Featured
SB-742457(RVT-101)
结构式
607742-69-8
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中国地区超过5000个高品质化合物库存
应用领域
Intepirdine (SB742457) 是5-HT6受体拮抗剂,pKi为9.63,比对其它受体的抑制性高100倍以上。
Cas No.: 607742-69-8
名称:
别名: SB 742457,RVT 101,SB742457,RVT101
SMILES: O=S(C1=CC2=CC=CC(N3CCNCC3)=C2N=C1)(C4=CC=CC=C4)=O
分子式: C19H19N3O2S
分子量: 353.12
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: SB-742457, also known as RVT-101, is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects. It was under development by GlaxoSmithKline for the treatment of Alzheimer's disease and demonstrated some preliminary efficacy in phase II clinical trials. SB742457 can reverse age-related declines in delayed non-match-to-sample performance (DNMS). SB742457 shows increasing pro-cognitive effects in patients with AD. For the detailed information of SB-742457(RVT-101), the solubility of SB-742457(RVT-101) in water, the solubility of SB-742457(RVT-101) in DMSO, the solubility of SB-742457(RVT-101) in PBS buffer, the animal experiment (test) of SB-742457(RVT-101), the cell expriment (test) of SB-742457(RVT-101), the in vivo, in vitro and clinical trial test of SB-742457(RVT-101), the EC50, IC50,and affinity,of SB-742457(RVT-101), For the detailed information of SB-742457(RVT-101), the solubility of SB-742457(RVT-101) in water, the solubility of SB-742457(RVT-101) in DMSO, the solubility of SB-742457(RVT-101) in PBS buffer, the animal experiment (test) of SB-742457(RVT-101), the cell expriment (test) of SB-742457(RVT-101), the in vivo, in vitro and clinical trial test of SB-742457(RVT-101), the EC50, IC50,and affinity,of SB-742457(RVT-101), Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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