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Idarubicin Hcl is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor.
IC50 Value: 3.3 ng/mL(in MCF-7 cells).
in vitro: Idarubicin is about 57.5-fold and 25-fold more active, respectively. Idarubicin is able to overcome P-glycoprotein-mediated multidrug resistance. Idarubicin inhibits PMN superoxide radical formation. Idarubicin could be coupled to the monoclonal antibodies (anti-Ly-2.1, anti-L3T4, or anti-Thy-1) with retention of protein solubility and antibody activity. Idarubicin inhibits the proliferation of NALM-6 cells with an IC50 of 12 nM. Idarubicin inhibits CYP450 2D6. Idarubicin is much more effective than doxorubicin or epirubicin.
in vivo: Reduction of Idarubicin is dependent upon ketone reductases, and proceeds more stereoselectively than that of most ketones giving rise to the (13S)-epimer almost exclusively. The high stereospecificity in Idarubicin reduction might result from chiral induction due to the presence of asymmetric centres near to the carbonyl group in Idarubicin. For the detailed information of Idarubicin hydrochloride, the solubility of Idarubicin hydrochloride in water, the solubility of Idarubicin hydrochloride in DMSO, the solubility of Idarubicin hydrochloride in PBS buffer, the animal experiment (test) of Idarubicin hydrochloride, the cell expriment (test) of Idarubicin hydrochloride, the in vivo, in vitro and clinical trial test of Idarubicin hydrochloride, the EC50, IC50,and affinity,of Idarubicin hydrochloride, For the detailed information of Idarubicin hydrochloride, the solubility of Idarubicin hydrochloride in water, the solubility of Idarubicin hydrochloride in DMSO, the solubility of Idarubicin hydrochloride in PBS buffer, the animal experiment (test) of Idarubicin hydrochloride, the cell expriment (test) of Idarubicin hydrochloride, the in vivo, in vitro and clinical trial test of Idarubicin hydrochloride, the EC50, IC50,and affinity,of Idarubicin hydrochloride, Please contact DC Chemicals. |
