UK-5099

产品编号: DC1111 Featured
UK-5099
结构式
56396-35-1
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中国地区超过5000个高品质化合物库存
应用领域
UK-5099 (PF-1005023) 是线粒体丙酮酸转运蛋白 (MPC) 的有效抑制剂, 抑制丙酮酸依赖性O2消耗的 IC50 值为50 nM。
Cas No.: 56396-35-1
名称:
别名: PF-1005023; UK5099; UK 5099; PF1005023; PF 1005023
SMILES: C([O-])(=O)/C(/C#N)=C/C1C2=C(N(C3=CC=CC=C3)C=1)C=CC=C2
分子式: C18H12N2O2
分子量: 288.31
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: UK-5099(PF1005023) is a potent inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC); inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM. IC50 value: 50 nM Target: MCT The trypanosomal pyruvate carrier was found to be rather insensitive to inhibition by alpha-cyano-4-hydroxycinnamate (Ki = 17 mM) but could be completely blocked by UK5099 (Ki = 49 microM). Inhibition of pyruvate transport resulted in the retention, and concomitant accumulation, of pyruvate within the trypanosomes, causing acidification of the cytosol and osmotic destabilization of the cells. UK-5099 is more powerful inhibitor than alpha-cyano-4-hydroxycinnamate showing 50% inhibition of pyruvate-dependent O2 consumption by rat heart mitochondria at concentrations of 200, 200 and 50 nM respectively. For the detailed information about the solubility of UK-5099 (UK5099 ) in water, the solubility of UK-5099 (UK5099 ) in DMSO, the solubility of UK-5099 (UK5099 ) in PBS buffer, the animal experiment(test) of UK-5099 (UK5099 ),the in vivo,in vitro and clinical trial test of UK-5099 (UK5099 ),the cell experiment(test) of UK-5099 (UK5099 ),the IC50, EC50 and Affinity of UK-5099 (UK5099 ), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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