CGP-57380
产品编号: DC7381
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应用领域
CGP 57380 是一种细胞渗透的吡唑-嘧啶类化合物，为具有选择性的 Mnk1 抑制剂，IC50 值为 2.2 μM，但是对 p38，JNK1，ERK1/2，PKC 或 Src-like 激酶等没有抑制作用。
| Cas No.: |
522629-08-9 |
| 名称: |
N3-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine |
| 别名: |
CGP57380; CGP-57380 |
| SMILES: |
C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F |
| 分子式: |
C11H9FN6 |
| 分子量: |
244.23 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
CGP57380 inhibits phosphorylation of eIF4E in cellular assays with IC50 of about 3 μM. CGP57380 causes dephosphorylation of eIF4E, and induces a further increase in the cap-dependent reporter in 293 cells. CGP57380 results in dose-dependent decreases in |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
