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SSR-240612 HCl

产品编号: DC10799 Featured
SSR-240612 HCl
结构式
464930-42-5
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中国地区超过5000个高品质化合物库存
应用领域
SSR240612 是一种有效的，可口服的，特异性的非肽类缓激肽 B1 (bradykinin B1) 受体拮抗剂，对 bradykinin B1 受体（在人 MRC5 细胞和表达人 B1 受体的 HEK 细胞）的 Ki 值分别为 0.48 nM，0.73 nM；对 B2 受体 (在豚鼠回肠膜和表达人 B1 受体的 CHO 细胞) 的 Ki 较弱，分别为 481 nM 和 358 nM。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 464930-42-5
名称: D-Phenylalaninamide, (3S)-3-(1,3-benzodioxol-5-yl)-N-((6-methoxy-2-naphthalenyl)sulfonyl)-beta-alanyl-4-(((2R,6S)-2,6-dimethyl-1-piperidinyl)methyl)-N-methyl-N-(1-methylethyl)-, hydrochloride (1:1)
别名: SSR-240612; SSR240612; SSR 240612
SMILES: O=C(NC([C@@H](C1=CC=C(OCO2)C2=C1)CNS(=O)(C3=CC=C4C=C(OC)C=CC4=C3)=O)=O)[C@@H](CC5=CC=C(CN6[C@H](C)CCC[C@@H]6C)C=C5)N(C)C(C)C.[H]Cl
分子式: C42H53ClN4O7S
分子量: 793.42
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: SSR240612 blocked tactile and cold allodynia at 3h (ID50=5.5and 7.1mg/kg,respectively) in glucose‐fed rats but had no effect in control rats. The antagonist (10mg/kg) had no effect on plasma glucose and insulin, insulin resistance (HOMA index) and aortic superoxide anion production in glucose-fed rats.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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