Macitentan (Actelion-1,ACT-064992)

产品编号: DC1012
Macitentan (Actelion-1,ACT-064992)
结构式
441798-33-0
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中国地区超过5000个高品质化合物库存
应用领域
macitentan (Actelion-1, ACT-064992) is an orally active, non-peptide dual endothelin (ET)A/B receptor antagonist with IC50 of 0.5 nM/391 nM.
Cas No.: 441798-33-0
名称: Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-
别名: ACT-064992,ACT064992
SMILES: BrC1=CN=C(OCCOC2=C(C3=CC=C(Br)C=C3)C(NS(NCCC)(=O)=O)=NC=N2)N=C1
分子式: C19H20Br2N6O4S
分子量: 588.27
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Description of Macitentan: Macitentan is an investigational drug being studied For the treatment of pulmonary arterial hypertension. It acts as a dual endothelin receptor antagonist and is being developed by Actelion. A Phase III clinical trial was successfully completed in 2012. For the detailed information about the solubility of macitentan (Actelion-1, ACT-064992) in water, the solubility of macitentan (Actelion-1, ACT-064992) in DMSO, the solubility of macitentan (Actelion-1, ACT-064992) in PBS buffer, the animal experiment(test) of macitentan (Actelion-1, ACT-064992),the in vivo,in vitro and clinical trial test of macitentan (Actelion-1, ACT-064992),the cell experiment(test) of macitentan (Actelion-1, ACT-064992),the IC50, EC50 and Affinity of macitentan (Actelion-1, ACT-064992), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_3326_DC1012_441798-33-0
COA
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产品编号 产品名称 应用领域
DC1012 Macitentan (Actelion-1,ACT-064992) macitentan (Actelion-1, ACT-064992) is an orally active, non-peptide dual endothelin (ET)A/B receptor antagonist with IC50 of 0.5 nM/391 nM.