PK11000
产品编号: DC10851
Featured
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
PK11000 是一种烷化剂，可通过共价半胱氨酸修饰来稳定野生型和突变型 p53 的 DNA 结合结构域，而不影响 DNA 的结合。
| Cas No.: |
38275-34-2 |
| 名称: |
5-Chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid |
| 别名: |
PK 11000，PK-11000，PK11000 |
| SMILES: |
CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl |
| 分子式: |
C6H5ClN2O4S |
| 分子量: |
236.6 |
| 纯度: |
|
| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
|
| In Vivo: |
|
| In Vitro: |
|
| References: |
PK11000 was able to increase the thermal stability of p53. This compound was then tested on p53 wild type, mutant, and knockout cancer cell lines to determine its effect both dependent and independent of a functional p53 protein. PK11000 reduced the viabi |
| Kinase Assay: |
|
| Cell Assay: |
|
| Animal Administration: |
|
| References: |
|
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
询盘
