Alda-1
产品编号: DC8723
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应用领域
Alda-1是有效的 ALDH2 激动剂，其激活野生型ALDH2并恢复近似野生型活性至ALDH2*2。
| Cas No.: |
349438-38-6 |
| 名称: |
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| 别名: |
ALDA1,ALDA 1 |
| SMILES: |
C(NCC1C=C2C(=CC=1)OCO2)(=O)C1=C(Cl)C=CC=C1Cl |
| 分子式: |
C15H11Cl2NO3 |
| 分子量: |
324.16 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
in vitro: ALDH2 is the oxidative enzyme, which removes the ethanol metabolite acetaldehyde and other aliphatic aldehydes. Also. ALDH2 is involved in bioconversion of vasodilator nitroglycerin to nitric oxide. Alda-1 increases acetaldehyde oxidation by ALDH2*1 (wild type) and ALDH2*2 9 Asian variant) approximately 1.5- and 6-fold, respectively. Alda-1 stimulates acetaldehyde oxidation by ALDH2 by improving NAD binding. Alda-1 activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.
in vivo: Alda-1 inhibits atherosclerosis and attenuates NAFLD in apoE-/- mice. The treatment with Alda-1 results in a significant decrease of TG level in liver of apoE-/- mice. |
| Kinase Assay: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2461_DC8723_349438-38-6 |
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COA
| LOT NO. |
DOWNLOAD |
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