Leukadherin-1
产品编号: DC9953
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应用领域
Leukadherin-1 是一种特异性的 CR3 和白细胞表面整合素 CD11b/CD18 的激动剂。
| Cas No.: |
344897-95-6 |
| 名称: |
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| 别名: |
Leukadherin 1,Leukadherin1 |
| SMILES: |
O=C(O)C1=CC=C(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)C=C1 |
| 分子式: |
C22H15NO4S2 |
| 分子量: |
421.49 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
Leukadherin-1 is a specific agonist of CR3 and the leukocyte surface integrin CD11b/CD18.In vitro: Leukadherin‐1 (LA1) modulates natural killer (NK) cell inflammatory cytokine secretion. The SLE-associated CD11b‐R77H variant does not influence NK cell response to Leukadherin-1. Leukadherin-1 does not modulate Syk activation in NK cells. Leukadherin-1 does not modulate Syk activation in NK cells. Leukadherin-1 (LA1) does not modulate signal transducer and activator of transcription (STAT)-4 phosphorylation. Leukadherin-1 modulates TLR-2 and TLR-7/8-induced monocyte cytokine secretion.
In vivo: Leukadherin-1 decreases macrophage infiltration in the lungs during hyperoxia. Furthermore, treatment with Leukadherin-1 improves alveolarization and angiogenesis and decreases pulmonary vascular remodeling and PH. Targeting leukocyte trafficking using Leukadherin-1, an integrin agonist, is beneficial in preventing lung inflammation and protecting alveolar and vascular structures during hyperoxia. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2904_DC9953_344897-95-6 |
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COA
| LOT NO. |
DOWNLOAD |
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